Furazolidone is a synthetic nitrofuran antibacterial and antiprotozoal agent. It has been used in pharmaceutical preparations for the treatment of certain bacterial and protozoal infections. Furazolidone belongs to the nitrofuran derivative class and is known for its broad antimicrobial activity.
Furazolidone is a pharmaceutical active ingredient used in antimicrobial drug development and formulations. It has historically been used for gastrointestinal infections and certain protozoal infections. Its antimicrobial activity results from reduction of the nitro group and formation of reactive intermediates that interfere with essential microbial cellular processes.
CAS Number: 59-87-0
Molecular Formula: C6H6N4O7
Molecular Weight: 238.16 g/mol
Drug Class: Nitrofuran Antibacterial / Antiprotozoal
Therapeutic Class: Anti-infective
Chemical Class: Nitrofurans
Physical State: Solid
Furazolidone is reduced by microbial enzymes to reactive metabolites. These metabolites can interfere with bacterial and protozoal enzymes and damage cellular components, ultimately inhibiting microbial growth.
Furazolidone has been used in the management of certain bacterial gastrointestinal infections and protozoal infections. Its historical applications include infections associated with susceptible microorganisms.
Furazolidone demonstrates activity against selected Gram-positive and Gram-negative bacteria as well as certain protozoa. Its antimicrobial effects are associated with intracellular reduction of its nitro group and subsequent formation of reactive intermediates.
Furazolidone is a synthetic nitrofuran derivative containing a nitrofuran ring and an oxazolidinone moiety. It has the molecular formula C6H6N4O7 and molecular weight 238.16 g/mol. It is characterized as a yellow crystalline solid and has limited solubility in water.
Furazolidone API quality evaluation may include identification by IR and HPLC, assay by HPLC, related substances, loss on drying, residue on ignition, residual solvents, elemental impurities and other applicable pharmaceutical quality-control tests.
Furazolidone should be stored in a tightly closed container under controlled pharmaceutical storage conditions and protected from excessive heat, moisture and direct light. Storage requirements should follow the applicable validated stability data and material-specific specification.
Furazolidone remains relevant to research involving nitrofuran chemistry, antimicrobial mechanisms and pharmaceutical analysis. Its chemical structure and antimicrobial activity make it a useful compound for appropriate pharmaceutical and analytical research.
Furazolidone is a synthetic nitrofuran antimicrobial compound identified by CAS Number 59-87-0, with molecular formula C6H6N4O7 and molecular weight 238.16 g/mol. It has antibacterial and antiprotozoal activity and has historically been used in pharmaceutical preparations for certain gastrointestinal and protozoal infections.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.0 – 7.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |
| Melting Point | 254 – 256°C |