Furagin, also known as furazidin, furazidine, or furazidin, is a synthetic nitrofuran derivative with antibacterial activity. It is primarily associated with the treatment of urinary tract infections and belongs to the nitrofuran class of antibacterial agents. Furagin is identified by CAS Number 1672-88-4, molecular formula C10H8N4O5, and molecular weight 264.19 g/mol.
Furagin API is a specialized antibacterial pharmaceutical ingredient used in pharmaceutical formulations and antimicrobial research. It is classified under the WHO ATC system as J01XE03 – Furazidin, within the nitrofuran derivatives group.
CAS Number: 1672-88-4
Molecular Formula: C10H8N4O5
Molecular Weight: 264.19 g/mol
Synonyms: Furazidin, Furazidine, NF-416, Furagin
ATC Classification: J01XE03
Drug Class: Nitrofuran Antibacterial
Therapeutic Class: Anti-infective / Antibacterial
Physical State: Solid
The chemical identity and molecular properties are confirmed by PubChem and FDA substance records.
Furagin belongs to the nitrofuran antibacterial group. Its antibacterial activity is associated with reduction of the nitro group and formation of reactive intermediates that can interfere with bacterial cellular processes. It has activity against various Gram-positive and Gram-negative microorganisms.
Furagin is primarily used as an antibacterial medicine for urinary tract infections. It has also been associated with antibacterial applications involving certain skin and soft-tissue infections.
Furagin contains a nitrofuran ring connected to a hydantoin-derived structure through an unsaturated side chain. The compound is achiral and has no defined stereocenters. It contains two E/Z stereochemical elements associated with its double-bond structure.
Furagin API quality evaluation may include identification by infrared spectroscopy, HPLC assay, related-substance testing, water determination, residue on ignition, residual solvents and elemental impurity assessment. Appropriate validated analytical procedures should be used for pharmaceutical quality control.
Furagin is a solid nitrofuran derivative with limited aqueous solubility. Its physicochemical properties depend on the solid form and testing conditions. Furazidin sodium and furazidin potassium are separate salt forms and should not be confused with the free compound.
Furagin should be stored in a tightly closed container under suitable pharmaceutical storage conditions and protected from excessive heat, moisture and direct light. Storage requirements should follow the applicable validated stability data and material-specific specification.
Furagin is relevant to pharmaceutical research involving nitrofuran antibacterial agents, urinary tract infection therapy and antimicrobial activity. Its established chemical identity and antibacterial classification make it a specialized pharmaceutical ingredient for appropriate formulations and research applications.
Furagin, also known as furazidin or furazidine, is a nitrofuran antibacterial compound with CAS Number 1672-88-4, molecular formula C10H8N4O5, and molecular weight 264.19 g/mol. It is primarily associated with antibacterial treatment of urinary tract infections and is classified under ATC J01XE03.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.0 – 7.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |