Fosaprepitant Dimeglumine API is a water-soluble phosphate prodrug of aprepitant and a selective neurokinin-1 (NK1) receptor antagonist. It is used as an active pharmaceutical ingredient in formulations intended for the prevention of chemotherapy-induced nausea and vomiting. Fosaprepitant Dimeglumine has CAS Number 265121-04-8, molecular formula C₃₇H₅₆F₇N₆O₁₆P, and molecular weight 1004.83 g/mol.
Fosaprepitant Dimeglumine is the 2:1 salt of fosaprepitant and N-methyl-D-glucamine (meglumine). It is chemically described as the dimeglumine salt of fosaprepitant. The substance is reported as a white to off-white amorphous powder and is freely soluble in water.
| Property | Value |
|---|---|
| CAS Number | 265121-04-8 |
| Molecular Formula | C₃₇H₅₆F₇N₆O₁₆P |
| Molecular Weight | 1004.83 g/mol |
| Salt Form | Dimeglumine salt |
| Parent Drug | Fosaprepitant |
| Appearance | White to off-white amorphous powder |
| Water Solubility | Freely soluble in water |
The molecular formula and molecular weight are confirmed by PubChem and the FDA/DailyMed drug description.
Unlike Fosamprenavir Calcium, I could not verify a current public USP monograph containing a complete numerical release specification for Fosaprepitant Dimeglumine. Therefore, I am not assigning generic limits for assay, impurities, heavy metals, LOD or water that are not specifically supported.
Commercial analytical suppliers report ≥95.0% purity, including HPLC/qNMR specifications from TCI and Cayman Chemical.
Fosaprepitant Dimeglumine is a prodrug of aprepitant and an NK1 receptor antagonist used in pharmaceutical preparations for the prevention of acute and delayed nausea and vomiting associated with chemotherapy.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 95.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 0.5% |