Forasartan is a synthetic nonpeptide angiotensin II receptor antagonist that selectively targets the angiotensin II type 1 (AT1) receptor. Also known by the development code SC-52458, Forasartan has been investigated for its antihypertensive activity and is studied for its ability to competitively inhibit angiotensin II binding at the AT1 receptor.
Forasartan API is a specialized pharmaceutical research compound used in cardiovascular pharmacology and angiotensin receptor research. Forasartan is identified by CAS Number 145216-43-9, with the molecular formula C23H28N8 and a molecular weight of approximately 416.52 g/mol. Its specialized nature makes it relevant to pharmaceutical research and development involving angiotensin II receptor antagonists.
Forasartan is a pyridine derivative containing tetrazole and triazole structural groups. Its systematic chemical name is 5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine. The compound belongs to the class of nonpeptide angiotensin II receptor antagonists and is primarily associated with AT1 receptor pharmacology.
Forasartan acts as a competitive and reversible antagonist of the angiotensin II type 1 receptor. By inhibiting angiotensin II activity at the AT1 receptor, Forasartan can reduce receptor-mediated effects such as vasoconstriction and aldosterone-related responses. This pharmacological activity makes Forasartan useful as a research compound for studying the renin-angiotensin system and cardiovascular regulation.
Forasartan has been investigated primarily in cardiovascular pharmacology and hypertension research. It has been studied as an orally active angiotensin II AT1 receptor antagonist and as a pharmacological research compound for investigating the renin-angiotensin system, vascular responses and mechanisms associated with blood pressure regulation.
Forasartan has the molecular formula C23H28N8 and a molecular weight of approximately 416.52 g/mol. The compound is achiral and has no defined stereocenters. Its calculated topological polar surface area is approximately 98.1 Ų. Forasartan contains multiple nitrogen atoms associated with its tetrazole and triazole functional groups and has hydrogen-bonding properties relevant to its molecular structure.
Quality evaluation of Forasartan API may include identity testing, chromatographic purity, assay determination, residual solvent testing, water content determination, elemental impurity assessment and other analytical controls appropriate to the intended research or pharmaceutical development application. Analytical testing should be performed using validated or appropriately qualified methods and evaluated against applicable specifications.
Forasartan should be stored in a tightly closed container under controlled laboratory conditions and protected from excessive heat, moisture and direct light. Handling and storage conditions should be established according to the applicable certificate of analysis, product documentation and available stability data.
Forasartan has been investigated as an angiotensin II receptor antagonist and used as a pharmacological research compound. Its selective activity at the AT1 receptor makes it relevant to studies involving cardiovascular pharmacology, vascular resistance, angiotensin II signaling and the renin-angiotensin system.
Forasartan is a specialized pharmaceutical research compound. Availability, batch size, packaging options, analytical documentation and export requirements can be evaluated according to the intended application and applicable regulatory requirements. Supporting documentation such as analytical specifications and certificates of analysis may be provided according to product and batch requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 139–141 °C |