Fluticasone API is a synthetic fluorinated corticosteroid with potent glucocorticoid activity. It is identified by CAS Number 90566-53-3, with the molecular formula C₂₂H₂₇F₃O₄S and molecular weight 444.51 g/mol.
Fluticasone is chemically identified as S-(fluoromethyl) 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate. It is a synthetic corticosteroid used in pharmaceutical preparations for local anti-inflammatory treatment.
Fluticasone has a molecular formula of C₂₂H₂₇F₃O₄S and molecular weight 444.51 g/mol. Its CAS Number is 90566-53-3. The reported melting point is approximately 237–239°C.
Fluticasone is practically insoluble in water and has limited solubility in organic solvents such as acetonitrile and chloroform.
Commercial analytical material for Fluticasone is available with a reported purity of ≥98.0%.
Important: Fluticasone CAS 90566-53-3 must not be confused with Fluticasone Propionate (CAS 80474-14-2). The USP monograph and pharmacopoeial assay range of 98.0–102.0% found in the references apply to Fluticasone Propionate, not the parent Fluticasone.
Fluticasone is a synthetic glucocorticoid used in pharmaceutical formulations for local anti-inflammatory applications, including respiratory and topical preparations.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Loss on Drying | NMT 1.0% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 1.0% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |
| Melting Point | 237–239°C |