Flurithromycin is a semisynthetic macrolide antibiotic and a fluorinated derivative of erythromycin A. It is also known as 8-Fluoroerythromycin and (8S)-8-Fluoroerythromycin A. The compound has the molecular formula C₃₇H₆₆FNO₁₃, molecular weight 751.9 g/mol, and CAS Registry Number 82664-20-8.
Flurithromycin is structurally related to erythromycin A, with fluorine replacing the hydrogen at the 8-position. It has been investigated and used as an antibacterial agent, particularly in the form of its monoethyl succinate ester.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Melting Point | >139°C (decomposition) |