Flupentixol is a thioxanthene-class antipsychotic compound that acts primarily as a dopamine receptor antagonist. Pharmaceutical products commonly use Flupentixol Dihydrochloride, the dihydrochloride salt of flupentixol. The BP/Ph. Eur. monograph identifies Flupentixol Hydrochloride as Flupentixol Dihydrochloride, with molecular formula C₂₃H₂₇Cl₂F₃N₂OS and molecular mass 507.4 g/mol.
Flupentixol exists as geometric isomers. The Z (cis) isomer is pharmacologically active, while the pharmaceutical monograph controls the proportion of the Z-isomer.
IUPAC/Systematic Name:
2-[4-[3-[(EZ)-2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethan-1-ol dihydrochloride.
Flupentixol Dihydrochloride is an antipsychotic API belonging to the thioxanthene group. It acts primarily through dopamine receptor antagonism and is used in pharmaceutical products for psychiatric disorders.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.1% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Melting Point | 150°C – 154°C |