Fluoxetine Hydrochloride (Fluoxetine HCl) is the hydrochloride salt of fluoxetine, a selective serotonin reuptake inhibitor (SSRI). It is used as an active pharmaceutical ingredient in medicines for major depressive disorder and other approved psychiatric conditions. Fluoxetine HCl has the molecular formula C₁₇H₁₈F₃NO·HCl and molecular weight 345.79 g/mol. Its CAS Registry Number is 59333-67-4.
Fluoxetine Hydrochloride is the hydrochloride salt of the racemic fluoxetine molecule. It is commonly incorporated into oral pharmaceutical formulations such as capsules, tablets and oral solutions.
Chemical Name:
N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride
Fluoxetine Hydrochloride is used in pharmaceutical formulations as an SSRI antidepressant. It is approved for indications including major depressive disorder, obsessive-compulsive disorder, bulimia nervosa and panic disorder, depending on the specific product and regulatory jurisdiction.
Fluoxetine selectively inhibits the neuronal reuptake of serotonin (5-HT), increasing serotonergic activity in the central nervous system. Its pharmacological effects are associated with increased serotonin availability at neuronal synapses.
Fluoxetine Hydrochloride is a crystalline solid. It is freely soluble in water and soluble in alcohol according to pharmaceutical reference information.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 4.5–6.5 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 168°C – 172°C |