Flumethasone Pivalate is a synthetic fluorinated corticosteroid ester with glucocorticoid, anti-inflammatory and antipruritic activity. It is also known as Flumetasone Pivalate and Flumethasone 21-Pivalate. The compound has CAS Number 2002-29-1, molecular formula C₂₇H₃₆F₂O₆, and molecular weight 494.57 g/mol.
Flumethasone Pivalate is a difluorinated corticosteroid ester used primarily in topical pharmaceutical preparations. It provides anti-inflammatory, antipruritic and vasoconstrictive effects at the site of application.
IUPAC Name:
[2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate.
Flumethasone Pivalate is used in topical corticosteroid preparations for inflammatory and pruritic dermatological conditions. Its corticosteroid activity helps reduce inflammation, exudation and itching.
Flumethasone Pivalate acts through glucocorticoid receptors. Topical corticosteroid activity suppresses inflammatory processes and reduces associated skin inflammation and itching.
PubChem reports Flumethasone Pivalate as a solid with a calculated molecular weight of 494.6 g/mol. An experimental melting point of approximately 219°C is reported for the base compound, while commercial analytical data report optical rotation under specified conditions.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 97.0%–103.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |