Fludroxycortide, also known as Flurandrenolide or Flurandrenolone, is a synthetic fluorinated corticosteroid used primarily as a topical anti-inflammatory medicine for various inflammatory and pruritic skin disorders. It is associated with topical products including creams, ointments and medicated adhesive tapes.
Fludroxycortide has the molecular formula C₂₄H₃₃FO₆, molecular weight 436.50 g/mol, and CAS Registry Number 1524-88-5. PubChem identifies the compound as CID 15209 and gives the FDA UNII as 8EUL29XUQT.
The systematic chemical name is:
6-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-(6α,11β,16α)-pregn-4-ene-3,20-dione
Fludroxycortide contains a corticosteroid nucleus with a fluorine substituent and a 16,17-acetonide structure.
Fludroxycortide is used topically for the treatment of inflammatory skin conditions. It is available in different topical formulations, including cream, ointment and medicated adhesive tape.
Fludroxycortide acts as a corticosteroid receptor agonist. Topical corticosteroids reduce inflammatory responses in the skin and provide anti-inflammatory and antipruritic effects.
Fludroxycortide has been marketed in topical formulations including:
Products associated with the substance include Cordran and Haelan.
Fludroxycortide is a defined chemical substance with established structural identifiers. For pharmaceutical-grade material, identity, assay, related substances, residual solvents, water content and other applicable quality attributes should be controlled according to the current applicable pharmacopoeial or approved product specification.
I have not inserted unsupported numerical limits for individual QC tests where an authoritative current numerical specification could not be verified.
Fludroxycortide API should be stored in a suitable, tightly closed pharmaceutical container under the conditions specified by the applicable approved specification. Handling should follow appropriate pharmaceutical occupational-safety procedures.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 3.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |