Fexofenadine Hydrochloride (Fexofenadine HCl) is a second-generation antihistamine and selective peripheral H1-receptor antagonist used in pharmaceutical formulations for the management of allergic conditions. It is the hydrochloride salt of fexofenadine and is associated with relief of symptoms of seasonal allergic rhinitis and urticaria.
Fexofenadine Hydrochloride has the molecular formula C₃₂H₃₉NO₄·HCl, molecular weight 538.12 g/mol, and CAS Number 153439-40-8.
Fexofenadine Hydrochloride is a relatively non-sedating antihistamine that selectively blocks peripheral histamine H1 receptors. Histamine is an important mediator of allergic symptoms, and blocking its interaction with H1 receptors helps reduce symptoms associated with allergic reactions.
Fexofenadine HCl is used as an active pharmaceutical ingredient in oral pharmaceutical formulations.
Fexofenadine acts primarily as a selective antagonist of peripheral H1 histamine receptors. By preventing histamine from activating these receptors, it reduces the physiological effects of histamine associated with allergic reactions.
This activity contributes to relief from symptoms such as sneezing, rhinorrhea, nasal and ocular itching, watery eyes and urticaria.
Fexofenadine Hydrochloride is used in pharmaceutical formulations for:
The specific indication, dosage and formulation should follow the applicable approved regulatory labeling.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |