Fenoterol is a synthetic short-acting β₂-adrenergic receptor agonist belonging to the resorcinol class of compounds. It is primarily associated with bronchodilator activity and acts on β₂-adrenergic receptors in airway smooth muscle. Fenoterol has CAS Number 13392-18-2, molecular formula C₁₇H₂₁NO₄, and molecular weight 303.35 g/mol.
Fenoterol is generally used in pharmaceutical formulations in the form of a salt, particularly Fenoterol Hydrobromide, which is a separate chemical substance from the parent Fenoterol. PubChem lists Fenoterol Hydrobromide under CAS 1944-12-3 with molecular weight 384.3 g/mol.
Fenoterol is a β₂-adrenergic agonist with bronchodilator and sympathomimetic properties. Activation of β₂ receptors increases intracellular cyclic AMP, resulting in relaxation of bronchial smooth muscle and bronchodilation.
Fenoterol is supplied as an active pharmaceutical ingredient for pharmaceutical research, development and manufacturing applications.
| Parameter | Details |
|---|---|
| Product Name | Fenoterol |
| CAS Number | 13392-18-2 |
| Molecular Formula | C₁₇H₂₁NO₄ |
| Molecular Weight | 303.35 g/mol |
| IUPAC Name | 5-[1-Hydroxy-2-[1-(4-hydroxyphenyl)propan-2-ylamino]ethyl]benzene-1,3-diol |
| Chemical Class | Resorcinol derivative |
| Pharmacological Class | β₂-Adrenergic receptor agonist |
| Therapeutic Area | Respiratory |
| Pharmacological Activity | Bronchodilator / Sympathomimetic |
Fenoterol stimulates β₂-adrenergic receptors, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP). The resulting relaxation of bronchial smooth muscle produces bronchodilation and helps relieve bronchospasm.
Fenoterol is associated with pharmaceutical applications involving:
Fenoterol has also been described as having tocolytic activity, although the applicable use depends on the country's regulatory authorization and formulation.
Fenoterol API is a synthetic small-molecule active pharmaceutical ingredient. Quality evaluation may include identification, assay, related substances, water content, residual solvents, elemental impurities and other applicable physicochemical characteristics.
The exact numerical acceptance criteria should be taken from the current approved manufacturer's specification and Certificate of Analysis (CoA).
Pharmaceutical-grade Fenoterol should be manufactured and tested according to applicable pharmaceutical quality and regulatory requirements.
Technical documentation may include:
Fenoterol API should be stored in a tightly closed container under the manufacturer's recommended storage conditions, protected from excessive heat, moisture and unsuitable light exposure.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 150°C – 154°C |