Fenoprofen is a synthetic non-steroidal anti-inflammatory drug (NSAID) belonging to the propionic acid derivative class. It possesses analgesic, anti-inflammatory and antipyretic properties and is associated with the inhibition of cyclooxygenase enzymes involved in prostaglandin synthesis.
Fenoprofen is identified by CAS Number 29679-58-1, molecular formula C₁₅H₁₄O₃, and molecular weight 242.27 g/mol. Its chemical name is 2-(3-phenoxyphenyl)propanoic acid.
Fenoprofen is an active pharmaceutical ingredient associated with the management of mild to moderate pain and inflammatory conditions. The calcium salt of Fenoprofen has been used in pharmaceutical formulations for the relief of pain and inflammation associated with disorders such as arthritis.
Fenoprofen belongs to the arylacetic acid/propionic acid derivative NSAID family and is supplied as a pharmaceutical active ingredient for pharmaceutical research, development and manufacturing applications.
| Parameter | Details |
|---|---|
| Product Name | Fenoprofen |
| CAS Number | 29679-58-1 |
| Molecular Formula | C₁₅H₁₄O₃ |
| Molecular Weight | 242.27 g/mol |
| Chemical Name | 2-(3-Phenoxyphenyl)propanoic acid |
| Drug Class | Non-steroidal anti-inflammatory drug (NSAID) |
| Chemical Class | Propionic acid derivative |
| Therapeutic Area | Pain / Inflammation |
| Pharmacological Activity | Analgesic, anti-inflammatory and antipyretic |
Fenoprofen, like other NSAIDs, exerts its pharmacological activity primarily through inhibition of cyclooxygenase (COX-1 and COX-2). This decreases prostaglandin synthesis. Prostaglandins contribute to pain and inflammation, so reduction of prostaglandin production contributes to Fenoprofen's analgesic and anti-inflammatory effects.
Fenoprofen is associated with pharmaceutical applications involving:
The approved indication and formulation should always be determined according to the applicable regulatory labeling.
Fenoprofen API is a synthetic small-molecule pharmaceutical active ingredient. Appropriate quality testing may include identification, assay, related substances, water content, residual solvents, elemental impurities and other applicable physicochemical parameters.
The exact acceptance criteria for commercial API should be based on the current approved manufacturer's specification and Certificate of Analysis (CoA).
Fenoprofen is commonly encountered in pharmaceutical products as Fenoprofen Calcium. Fenoprofen Calcium is a separate salt form and should not be confused with the parent Fenoprofen API.
Current U.S. labeling describes Fenoprofen Calcium as the dihydrate, with molecular formula C₃₀H₂₆CaO₆·2H₂O and molecular weight 558.65 g/mol. It is described as a white crystalline powder, slightly soluble in water and soluble in 95% alcohol.
Pharmaceutical-grade Fenoprofen should be manufactured and tested according to applicable pharmaceutical quality and regulatory requirements.
Technical documentation may include:
Fenoprofen API should be stored in a tightly closed container under the manufacturer's recommended storage conditions, protected from excessive moisture, heat and direct light. The manufacturer's validated storage conditions should be followed for commercial material.
We provide Fenoprofen API for pharmaceutical research, development and manufacturing requirements, subject to applicable quality, regulatory and commercial requirements.
Customers can contact us for Fenoprofen API availability, specifications, Certificate of Analysis (CoA), technical documentation and bulk supply requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |