Fasudil Hydrochloride is the hydrochloride salt of Fasudil, a small-molecule Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor. It is also known by synonyms including Fasudil HCl, HA-1077 hydrochloride, and AT-877 hydrochloride. Fasudil Hydrochloride has CAS Number 105628-07-7, molecular formula C₁₄H₁₈ClN₃O₂S, and molecular weight 327.8 g/mol.
Fasudil Hydrochloride is a pharmaceutical active ingredient belonging to the Rho kinase inhibitor class. It acts on ROCK signaling, a pathway involved in vascular smooth-muscle contraction, cellular migration, cytoskeletal organization and other physiological processes. KEGG classifies Fasudil Hydrochloride under protein kinase-targeting drugs, specifically the ROCK group.
| Parameter | Details |
|---|---|
| Product Name | Fasudil Hydrochloride |
| Synonyms | Fasudil HCl, HA-1077 Hydrochloride, AT-877 Hydrochloride |
| CAS Number | 105628-07-7 |
| Molecular Formula | C₁₄H₁₈ClN₃O₂S |
| Molecular Weight | 327.8 g/mol |
| IUPAC Name | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline; hydrochloride |
| Drug Class | Rho Kinase (ROCK) Inhibitor |
| Chemical Type | Small-Molecule Hydrochloride Salt |
| UNII | SQ04N8S7BR |
These identity details are supported by PubChem and the FDA Substance Registration System.
Fasudil Hydrochloride acts primarily as a Rho kinase inhibitor. Inhibition of the Rho/ROCK signaling pathway can reduce ROCK-mediated phosphorylation and influence vascular smooth-muscle contraction and cellular cytoskeletal processes.
The compound has been characterized as a kinase inhibitor and vasodilator, with Fasudil Hydrochloride listed in drug databases as a ROCK-targeting compound.
Fasudil Hydrochloride has been used in pharmaceutical applications associated with cerebral vasospasm, particularly following subarachnoid hemorrhage. The hydrochloride hydrate form is described in PubChem as a drug used for prevention of cerebral vasospasm and ensuing cerebral ischemia following surgery for subarachnoid hemorrhage.
Potential pharmaceutical applications and approved indications can vary by country, formulation and regulatory authorization, so product pages should not imply an indication beyond the applicable approved labeling.
Fasudil Hydrochloride is a small-molecule pharmaceutical API suitable for pharmaceutical research, development and manufacturing applications where the hydrochloride form is required.
Quality assessment of the API may include:
Exact release specifications should be based on the current manufacturer's approved specification and Certificate of Analysis (CoA).
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |