Fasudil is a pharmaceutical active ingredient belonging to the class of Rho-associated protein kinase (ROCK) inhibitors. It is also known by the development code HA-1077. Fasudil has the CAS Number 103745-39-7, molecular formula C₁₄H₁₇N₃O₂S, and molecular weight 291.37 g/mol.
Fasudil API is used as an active pharmaceutical ingredient and as a pharmaceutical research and development compound. It acts as a Rho kinase inhibitor and has been investigated for its vasodilatory and neuroprotective properties.
Fasudil is chemically identified as 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline. The compound has a molecular formula of C₁₄H₁₇N₃O₂S and molecular weight of 291.37 g/mol. Its CAS Registry Number is 103745-39-7.
Fasudil is a ROCK inhibitor associated with vasodilatory activity and has been used or investigated in pharmaceutical applications involving vascular and neurological conditions. The hydrochloride hydrate form has been used for the prevention of cerebral vasospasm and subsequent cerebral ischemia following surgery for subarachnoid hemorrhage.
Fasudil Hydrochloride is the hydrochloride salt of Fasudil and should be distinguished from the parent Fasudil compound. Fasudil Hydrochloride has CAS Number 105628-07-7, molecular formula C₁₄H₁₈ClN₃O₂S, and molecular weight 327.8 g/mol.
Fasudil API should be manufactured and tested according to the applicable pharmaceutical quality requirements and the approved product specification. Quality evaluation may include identification, assay, related substances, water content, residue on ignition and other applicable physicochemical quality parameters.
The actual acceptance criteria should be confirmed against the current manufacturer's specification and Certificate of Analysis (COA) for the supplied material.
We provide Fasudil API for pharmaceutical and research-related requirements, subject to applicable quality, regulatory and commercial requirements. Product documentation, specifications, COA and availability can be provided according to customer requirements.
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| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 1.0% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |