Fampridine is a synthetic small-molecule potassium channel blocker and active pharmaceutical ingredient (API). It is also known as 4-aminopyridine (4-AP) and is used to improve walking ability in certain adults with multiple sclerosis (MS).
Fampridine works by blocking voltage-gated potassium channels on demyelinated nerve fibers, helping improve the conduction of electrical signals along affected nerves.
Fampridine is a 4-aminopyridine derivative that acts primarily by blocking voltage-gated potassium channels. In demyelinated axons, this mechanism can help restore or improve action-potential conduction.
CAS Number: 504-24-5
Molecular Formula: C₅H₆N₂
Molecular Weight: 94.12 g/mol
Fampridine blocks voltage-gated potassium channels in neuronal membranes.
Its pharmacological effects include:
Fampridine is used in pharmaceutical formulations for:
The exact indication, dosage and patient eligibility depend on the approved formulation and applicable regulatory labeling.
Fampridine is a small-molecule pharmaceutical API with defined chemical and physicochemical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Fampridine should comply with the applicable approved specification and relevant regulatory requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Fampridine in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 1.0% |