Famitinib is a synthetic small-molecule tyrosine kinase inhibitor (TKI) and active pharmaceutical ingredient (API). It has been investigated as an anticancer agent, particularly for its ability to inhibit signaling pathways involved in tumor angiogenesis and cancer cell proliferation.
Famitinib has activity against multiple receptor tyrosine kinases, including VEGFR, PDGFR and c-Kit, making it relevant to oncology drug-development research.
Famitinib is an orally active multi-target kinase inhibitor investigated for the treatment of various solid tumors. Its pharmacological activity is associated primarily with inhibition of receptor tyrosine kinases involved in angiogenesis and tumor growth.
CAS Number: 852808-04-9
Molecular Formula: C₂₇H₂₈N₄O₃
Molecular Weight: 456.54 g/mol
Famitinib inhibits selected receptor tyrosine kinases involved in tumor growth and angiogenesis.
Its pharmacological effects include:
Famitinib has been investigated in oncology research for:
Regulatory status and approved indications should be verified for the applicable market before making therapeutic claims.
Famitinib is a small-molecule oncology API with defined chemical and physicochemical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Famitinib should comply with the applicable approved specification and relevant regulatory requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Famitinib in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |