Evocalcet is a synthetic calcimimetic active pharmaceutical ingredient (API) that acts as an allosteric activator of the calcium-sensing receptor (CaSR). It is used to regulate parathyroid hormone (PTH) secretion and is primarily associated with the treatment of secondary hyperparathyroidism in patients with chronic kidney disease undergoing dialysis.
Evocalcet is an orally active calcimimetic compound that increases the sensitivity of the calcium-sensing receptor to extracellular calcium. This suppresses excessive PTH secretion and helps regulate calcium and phosphorus metabolism.
CAS Number: 1264206-74-7
Molecular Formula: C₁₅H₁₃F₃N₂O
Molecular Weight: 294.27 g/mol
Evocalcet acts as an allosteric agonist of the calcium-sensing receptor (CaSR) located on parathyroid cells.
Its pharmacological effects include:
Evocalcet is used in pharmaceutical formulations for:
The exact indication, dosage and patient population depend on the approved product labeling and applicable regulatory requirements.
Evocalcet is a small-molecule calcimimetic API with defined chemical and physicochemical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances, stereochemical purity and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Evocalcet should comply with the applicable approved specification and relevant regulatory requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Evocalcet in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 0.5% |