Etripamil is a short-acting, locally administered calcium channel blocker and active pharmaceutical ingredient (API) being developed for the rapid treatment of certain cardiovascular conditions. It is a dihydropyridine-type calcium channel blocker designed for intranasal administration.
Etripamil acts primarily by blocking L-type calcium channels in vascular smooth muscle, producing rapid vasodilation and reducing vascular resistance.
Etripamil is a synthetic, short-acting calcium channel blocker developed for rapid-onset cardiovascular therapy. Its intranasal route is designed to provide fast local/systemic drug delivery.
CAS Number: 1264171-55-8
Molecular Formula: C₂₈H₄₃N₃O₄
Molecular Weight: 485.67 g/mol
Etripamil blocks L-type voltage-gated calcium channels in vascular smooth muscle. This reduces calcium influx into smooth-muscle cells and promotes vasodilation.
Its pharmacological effects include:
Etripamil has been investigated primarily for:
Regulatory status and approved indications should be verified for the applicable market before making marketing or therapeutic claims.
Etripamil is a small-molecule cardiovascular API with defined chemical and physicochemical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances, stereochemical purity and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Etripamil should comply with the applicable approved specification and relevant regulatory requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Etripamil in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0% by HPLC |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |