Etrasimod is an orally active, selective sphingosine-1-phosphate (S1P) receptor modulator and active pharmaceutical ingredient (API). It is designed to modulate lymphocyte trafficking and is used therapeutically in certain immune-mediated inflammatory diseases.
Etrasimod selectively targets S1P receptor subtypes and reduces the circulation of certain lymphocytes, thereby modulating immune responses.
Etrasimod is a synthetic small-molecule immunomodulatory agent administered orally. It has activity primarily at S1P receptor subtypes 1, 4 and 5 (S1P₁, S1P₄ and S1P₅).
CAS Number: 1206123-37-6
Molecular Formula: C₂₆H₂₆F₃N₅O₃
Molecular Weight: 513.52 g/mol
Etrasimod acts as a selective modulator of S1P receptors, particularly S1P₁, S1P₄ and S1P₅.
Its immunological effects include:
Etrasimod is used in approved pharmaceutical formulations for:
The exact therapeutic application depends on the approved formulation, country and applicable regulatory labeling.
Etrasimod is a small-molecule immunomodulatory API with defined chemical and physicochemical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances, stereochemical purity and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Etrasimod should comply with the applicable approved specification and relevant regulatory requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Etrasimod in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0% by HPLC |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |