Etomidate is a short-acting intravenous anesthetic active pharmaceutical ingredient (API) used primarily for the induction of general anesthesia. It is a substituted imidazole derivative known for producing rapid hypnotic effects with comparatively limited cardiovascular depression.
Etomidate is particularly used in clinical settings where maintenance of cardiovascular stability during induction is an important consideration.
Etomidate is a short-acting hypnotic agent administered intravenously. It produces anesthesia primarily through enhancement of inhibitory neurotransmission mediated by GABA-A receptors in the central nervous system.
CAS Number: 33125-97-2
Molecular Formula: C₁₄H₁₆N₂O₂
Molecular Weight: 244.29 g/mol
Etomidate enhances the activity of gamma-aminobutyric acid (GABA) at GABA-A receptors in the central nervous system. This increases inhibitory neurotransmission and produces hypnosis and loss of consciousness.
Its pharmacological effects include:
Etomidate is used in pharmaceutical formulations for:
The exact therapeutic application depends on the formulation, country and applicable regulatory labeling.
Etomidate is an intravenous anesthetic API with defined chemical and physicochemical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Etomidate should comply with the applicable approved specification, pharmacopoeial requirements where applicable, and relevant regulatory standards.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Etomidate in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |