Etilefrine is a synthetic sympathomimetic agent and active pharmaceutical ingredient (API) with predominantly α-adrenergic activity. It is used as a vasopressor to increase vascular tone and blood pressure in certain forms of hypotension.
Etilefrine acts primarily by stimulating adrenergic receptors, resulting in increased vascular resistance and cardiovascular effects.
Etilefrine is a phenethylamine derivative with direct and indirect sympathomimetic properties. It is commonly encountered as Etilefrine Hydrochloride in pharmaceutical formulations.
CAS Number: 709-98-8
Molecular Formula: C₁₀H₁₅NO₂
Molecular Weight: 181.23 g/mol
Etilefrine stimulates adrenergic receptors, particularly α-adrenergic receptors, leading to vasoconstriction and increased vascular tone.
Its pharmacological effects include:
Etilefrine is used in pharmaceutical formulations for:
The exact therapeutic application depends on the formulation, country and applicable regulatory labeling.
Etilefrine is a sympathomimetic pharmaceutical ingredient with defined chemical and physicochemical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Etilefrine should comply with the applicable approved specification, pharmacopoeial requirements where applicable, and relevant regulatory standards.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Etilefrine in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Conforms to USP identification tests |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | NMT 2.0% |