Ethynodiol Diacetate is a synthetic progestin and an active pharmaceutical ingredient (API) used primarily in hormonal contraceptive formulations. It is a derivative of 19-nortestosterone and acts as a progestational agent.
Ethynodiol Diacetate is used in combination with an estrogen in certain combined oral contraceptive formulations, where its progestogenic activity contributes to suppression of ovulation and prevention of pregnancy.
Ethynodiol Diacetate is the diacetate ester of ethynodiol, a synthetic progestin. It is metabolized in the body to ethynodiol, which has progestational activity.
CAS Number: 297-76-7
Molecular Formula: C₂₄H₃₄O₄
Molecular Weight: 386.53 g/mol
Ethynodiol Diacetate exerts progestational effects primarily through interaction with progesterone receptors.
In combined oral contraceptive formulations, its effects include:
Ethynodiol Diacetate is used in pharmaceutical formulations for:
The exact use depends on the final formulation, country and applicable regulatory labeling.
Ethynodiol Diacetate is a steroidal progestin API with defined chemical and stereochemical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Ethynodiol Diacetate should comply with the applicable pharmacopoeial monograph, approved specification and regulatory requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Ethynodiol Diacetate in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |