Ethoxzolamide is a carbonic anhydrase inhibitor and an active pharmaceutical ingredient (API). It belongs to the sulfonamide class of medicines and has been investigated and used for its ability to inhibit carbonic anhydrase enzymes, thereby influencing bicarbonate transport and fluid balance.
Ethoxzolamide has been associated with diuretic and ocular pharmacological effects and has applications in pharmaceutical and research settings.
Ethoxzolamide is a synthetic sulfonamide derivative that inhibits carbonic anhydrase. By reducing carbonic anhydrase activity, it decreases bicarbonate reabsorption and alters the formation and movement of aqueous humor and other physiological fluids.
CAS Number: 452-35-7
Molecular Formula: C₉H₁₀N₄O₃S₂
Molecular Weight: 286.33 g/mol
Ethoxzolamide inhibits carbonic anhydrase (CA) enzymes. Carbonic anhydrase catalyzes the reversible conversion of carbon dioxide and water into carbonic acid, which dissociates into bicarbonate and hydrogen ions.
Inhibition of the enzyme can result in:
Ethoxzolamide has been used or investigated for applications associated with carbonic anhydrase inhibition, including:
The exact therapeutic use depends on the formulation, market authorization and applicable regulatory labeling.
Ethoxzolamide is a sulfonamide carbonic anhydrase inhibitor API with defined chemical and physical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Ethoxzolamide should comply with the applicable approved specification and relevant regulatory requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Ethoxzolamide in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 150°C – 154°C |