Ethosuximide is an anticonvulsant active pharmaceutical ingredient (API) belonging to the succinimide class. It is primarily used for the management of absence seizures (petit mal seizures).
Ethosuximide works mainly by reducing abnormal electrical activity in the brain through inhibition of T-type calcium currents in thalamic neurons, which are important in the generation of absence seizures.
Ethosuximide is a synthetic succinimide derivative with anticonvulsant activity. It is particularly selective for absence seizures and is available as an active pharmaceutical ingredient for approved pharmaceutical formulations.
CAS Number: 77-67-8
Molecular Formula: C₇H₁₁NO₂
Molecular Weight: 141.17 g/mol
Ethosuximide primarily inhibits T-type calcium channels in thalamic neurons. This reduces the rhythmic thalamocortical activity associated with absence seizures.
Its pharmacological effects include:
Ethosuximide is used in pharmaceutical formulations for:
Ethosuximide is particularly associated with the treatment of absence seizures rather than generalized tonic-clonic or focal seizures.
Ethosuximide is a succinimide anticonvulsant API with defined chemical and physical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Ethosuximide should comply with the applicable pharmacopoeial monograph, approved specification and regulatory requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Ethosuximide in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |