Ethacrynic Acid is a potent loop diuretic and an active pharmaceutical ingredient (API) used in pharmaceutical formulations for the management of edema associated with various medical conditions. It acts primarily on the Na⁺-K⁺-2Cl⁻ cotransporter (NKCC2) in the thick ascending limb of the loop of Henle, increasing the excretion of sodium, chloride and water.
Ethacrynic Acid is a non-sulfonamide loop diuretic, making it chemically distinct from several other commonly used loop diuretics.
Ethacrynic Acid is a phenoxyacetic acid derivative with potent diuretic activity. It inhibits electrolyte reabsorption in the renal tubules and produces a rapid increase in urine formation.
CAS Number: 58-54-8
Molecular Formula: C₁₃H₁₂Cl₂O₄
Molecular Weight: 303.14 g/mol
Ethacrynic Acid inhibits the Na⁺-K⁺-2Cl⁻ cotransporter (NKCC2) in the thick ascending limb of the loop of Henle.
This results in:
Ethacrynic Acid is also known for its non-sulfonamide chemical structure.
Ethacrynic Acid is used in pharmaceutical formulations for:
The exact indication depends on the final pharmaceutical formulation and applicable regulatory labeling.
Ethacrynic Acid is a loop diuretic API with defined chemical and physical characteristics. Pharmaceutical-grade material requires appropriate control of identity, assay, related substances and other quality attributes.
Typical quality evaluation may include:
Pharmaceutical-grade Ethacrynic Acid should comply with the applicable approved specification and relevant pharmacopoeial and regulatory requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Ethacrynic Acid in a tightly closed container, protected from excessive moisture, heat and direct light, according to the manufacturer's approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Water Content | NMT 1.0% |
| Melting Point | 150°C – 154°C |