Estrone-3-Sulphate is a sulfate conjugate of estrone, an endogenous steroidal estrogen. It is an estrogen metabolite and serves as an important intermediate and reservoir form of estrogen in biological systems. Estrone-3-sulfate is also used in pharmaceutical and biochemical research applications.
Estrone-3-sulfate can undergo enzymatic conversion to estrone, which may subsequently participate in estrogenic signaling. Its sulfate-conjugated structure influences its solubility, transport and metabolism.
Estrone-3-Sulphate is the 3-sulfate ester of estrone. It belongs to the family of steroid sulfate conjugates and is formed naturally through sulfation of estrone.
CAS Number: 481-97-8
Molecular Formula: C₁₈H₂₂O₆S
Molecular Weight: 366.43 g/mol
Estrone-3-sulfate itself is a conjugated, relatively inactive estrogen reservoir. It can be hydrolyzed by steroid sulfatase (STS) to generate estrone, which can then contribute to estrogen receptor-mediated activity.
Its biological relevance includes:
Estrone-3-Sulphate may be used in:
Its exact use depends on the grade, specification and intended application.
Estrone-3-Sulphate is a steroidal sulfate conjugate with defined chemical structure and stereochemistry. Quality evaluation should control identity, purity, related substances, water content and other applicable quality attributes.
Typical analytical evaluation may include:
Pharmaceutical or research-grade Estrone-3-Sulphate should comply with the applicable approved specification and intended-use requirements.
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Store Estrone-3-Sulphate in a tightly closed container, protected from moisture, excessive heat and direct light, according to the applicable manufacturer-approved storage conditions.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Total Impurities | NMT 1.0% |