Esomeprazole is a proton pump inhibitor (PPI) and the S-enantiomer of omeprazole. It reduces gastric acid secretion by specifically inhibiting the gastric H⁺/K⁺-ATPase proton pump in the parietal cells of the stomach.
Esomeprazole is widely used as an active pharmaceutical ingredient in medicines for acid-related gastrointestinal disorders, including gastroesophageal reflux disease, peptic ulcer disease and conditions associated with excessive gastric acid secretion.
Esomeprazole is a substituted benzimidazole derivative and belongs to the proton pump inhibitor class. It is commonly supplied in pharmaceutical products as esomeprazole magnesium or other approved salt forms.
The molecular formula of Esomeprazole is C₁₇H₁₉N₃O₃S, with a molecular weight of approximately 345.42 g/mol. The CAS Registry Number is 119141-88-7.
Esomeprazole suppresses gastric acid production by inhibiting the H⁺/K⁺-ATPase enzyme system in gastric parietal cells.
This results in:
Esomeprazole is a prodrug that becomes activated in the acidic environment of the secretory canaliculi of gastric parietal cells.
Esomeprazole is primarily used in pharmaceutical formulations for:
The exact approved indications depend on the applicable regulatory product labeling.
Esomeprazole is a chiral small-molecule pharmaceutical API belonging to the proton pump inhibitor class. Its stereochemical purity is an important quality attribute because Esomeprazole represents the S-enantiomer of omeprazole.
Commercial pharmaceutical products may use different approved salt or formulation forms, including esomeprazole magnesium. Therefore, the API name, molecular formula, molecular weight and CAS number in your CMS should correspond to the exact form being supplied.
Pharmaceutical-grade Esomeprazole intended for manufacturing should comply with the applicable approved specification and relevant pharmacopoeial and regulatory requirements.
Typical quality-control parameters include:
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Esomeprazole should be stored in a tightly closed container, protected from excessive moisture, heat and direct light, according to the applicable approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Water Content | NMT 1.0% |