Esmolol Hydrochloride is a short-acting, cardioselective beta-1 adrenergic receptor blocker used as an active pharmaceutical ingredient in cardiovascular medicines. Its rapid onset and short duration of action make it suitable for situations where temporary and precisely controlled beta-blockade is required.
Esmolol Hydrochloride is the hydrochloride salt of esmolol and is primarily used in intravenous pharmaceutical formulations for short-term control of heart rate and certain cardiovascular conditions.
Esmolol Hydrochloride is a synthetic ultra-short-acting beta-adrenergic blocker with preferential activity at beta-1 receptors in cardiac tissue.
CAS Number: 81147-84-2
Molecular Formula: C₁₆H₂₆ClNO₄
Molecular Weight: 331.84 g/mol
Esmolol Hydrochloride competitively blocks beta-1 adrenergic receptors, reducing the effects of catecholamines on the heart.
This produces:
Esmolol is rapidly hydrolyzed by esterases in red blood cells, contributing to its very short duration of action.
Esmolol Hydrochloride is used in pharmaceutical formulations for:
The exact approved indications depend on the applicable regulatory labeling.
Esmolol Hydrochloride is a small-molecule cardiovascular API belonging to the beta-blocker class. It is particularly suited to injectable pharmaceutical formulations requiring rapid onset and rapid adjustment of beta-adrenergic blockade.
Quality testing generally includes identification, assay, related substances, water content, residual solvents and other applicable physicochemical parameters.
Pharmaceutical-grade Esmolol Hydrochloride should comply with the applicable approved specification and relevant pharmacopoeial and regulatory requirements.
Typical quality-control parameters include:
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Esmolol Hydrochloride should be stored in a tightly closed container, protected from excessive moisture, heat and direct light, according to the applicable approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |