Esflurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) and the S-enantiomer of flurbiprofen. It belongs to the propionic acid derivative class of NSAIDs and produces analgesic and anti-inflammatory effects primarily through inhibition of cyclooxygenase (COX) enzymes.
Esflurbiprofen is used as an active pharmaceutical ingredient in formulations intended for the management of pain and inflammation. It is also used in ophthalmic pharmaceutical applications in certain markets.
Esflurbiprofen is the pharmacologically active S-enantiomer of flurbiprofen. It inhibits prostaglandin synthesis by reducing cyclooxygenase-mediated conversion of arachidonic acid to prostaglandins.
The molecular formula of Esflurbiprofen is C₁₅H₁₃FO₂, with a molecular weight of approximately 244.26 g/mol. The CAS Registry Number is 51543-39-6.
Esflurbiprofen inhibits cyclooxygenase (COX) enzymes, reducing the formation of prostaglandins involved in pain and inflammation.
This results in:
Esflurbiprofen is associated with pharmaceutical formulations for:
Esflurbiprofen is a small-molecule NSAID API and the active S-enantiomer of flurbiprofen.
For pharmaceutical manufacturing, Esflurbiprofen is evaluated using analytical methods for identity, assay, stereochemical purity, related substances, residual solvents, water content and other applicable quality attributes.
Because Esflurbiprofen is a chiral API, control of enantiomeric purity is an important quality consideration.
Pharmaceutical-grade Esflurbiprofen intended for manufacturing should comply with the applicable approved specification and relevant pharmacopoeial and regulatory requirements.
Typical quality-control parameters include:
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Esflurbiprofen should be stored in a tightly closed container, protected from excessive moisture, heat and direct light, according to the applicable approved storage and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0% by HPLC |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Melting Point | 168°C – 172°C |