Esaxerenone is a synthetic, non-steroidal mineralocorticoid receptor (MR) antagonist used as an active pharmaceutical ingredient in medicines for cardiovascular and renal conditions. It selectively inhibits the mineralocorticoid receptor and reduces the effects of excessive aldosterone signaling.
Esaxerenone is a small-molecule pharmaceutical compound developed as a selective mineralocorticoid receptor blocker. It is primarily associated with the management of hypertension, particularly in patients with diabetic kidney disease in applicable clinical settings.
Esaxerenone is a non-steroidal mineralocorticoid receptor antagonist. Unlike steroidal MR antagonists, it has a non-steroidal chemical structure and is designed to selectively inhibit mineralocorticoid receptor activity.
The molecular formula of Esaxerenone is C₂₂H₂₁ClF₂N₄O₃, with a molecular weight of approximately 462.88 g/mol. The CAS Registry Number is 1636800-77-7.
Esaxerenone selectively binds to and antagonizes the mineralocorticoid receptor (MR).
By blocking aldosterone-mediated MR activation, Esaxerenone can reduce:
Esaxerenone is primarily associated with:
Esaxerenone is a small-molecule pharmaceutical API belonging to the non-steroidal mineralocorticoid receptor antagonist class.
Pharmaceutical-grade Esaxerenone is evaluated using analytical procedures appropriate for identity, assay, related substances, residual solvents, water content and other applicable quality attributes.
Esaxerenone API intended for pharmaceutical manufacturing should comply with the applicable approved specification and regulatory requirements.
Typical quality-control parameters include:
A qualified supplier should provide Certificate of Analysis (CoA), specification sheet, SDS/MSDS, batch traceability and applicable regulatory documentation.
Esaxerenone should be stored in a tightly closed container, protected from excessive moisture, heat and direct light, according to the applicable approved storage specification and stability requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0% by HPLC |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 150°C – 154°C |