Eprosartan is an orally active angiotensin II receptor blocker (ARB) used in the management of hypertension. It selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from producing vasoconstriction and other effects that contribute to elevated blood pressure.
Eprosartan belongs to the angiotensin II receptor antagonist class of pharmaceutical compounds. Unlike ACE inhibitors, eprosartan acts directly at the angiotensin II receptor and does not inhibit the angiotensin-converting enzyme.
Eprosartan is a synthetic, non-peptide angiotensin II receptor antagonist. It selectively inhibits the binding of angiotensin II to the AT1 receptor, resulting in reduced vasoconstriction and decreased aldosterone-mediated sodium and water retention.
Eprosartan has the molecular formula C₂₃H₂₄N₂O₄S and a molecular weight of approximately 424.52 g/mol. Its CAS number is 133040-01-4.
Eprosartan selectively blocks the AT1 receptor for angiotensin II.
By inhibiting angiotensin II activity, eprosartan:
Eprosartan does not inhibit ACE and therefore does not directly interfere with bradykinin metabolism.
Eprosartan is primarily associated with:
Swapnroop Drugs and Pharmaceuticals provides Eprosartan API for qualified pharmaceutical manufacturing, formulation development, research and pharmaceutical sourcing requirements.
Pharmaceutical-grade Eprosartan can be supported with appropriate quality documentation, analytical specifications and batch-related documentation according to applicable requirements.
Eprosartan API intended for pharmaceutical manufacturing should comply with the applicable approved specification and relevant pharmacopoeial or regulatory requirements. Typical quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities and other applicable physicochemical parameters.
Eprosartan API should be stored in a tightly closed container, protected from moisture, excessive heat and direct light, under conditions specified in the applicable approved specification and stability documentation.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |