Epinastine Hydrochloride is the hydrochloride salt of Epinastine, a second-generation histamine H1 receptor antagonist with antiallergic activity. It inhibits histamine-mediated allergic responses and also suppresses the release of histamine from mast cells.
Epinastine Hydrochloride is used in pharmaceutical products for the management of allergic conditions, particularly allergic conjunctivitis. Epinastine has also been described as having affinity for H2, 5-HT2 and alpha-adrenergic receptors.
Epinastine Hydrochloride is a synthetic antihistamine and antiallergic pharmaceutical ingredient. The hydrochloride salt has the molecular formula C₁₆H₁₆ClN₃, molecular weight 285.77 g/mol, and CAS number 108929-04-0.
It is also known as Epinastine HCl, Epinastine Hydrochloride, WAL-801CL, and WAL 801 CL.
Swapnroop Drugs and Pharmaceuticals provides Epinastine Hydrochloride for qualified pharmaceutical manufacturing, formulation development, research and pharmaceutical sourcing requirements.
Epinastine Hydrochloride is a specialized antihistamine API suitable for pharmaceutical applications involving allergic and ophthalmic formulations.
Epinastine Hydrochloride acts primarily as a histamine H1 receptor antagonist. By blocking H1 receptors, it reduces the effects of histamine responsible for allergic symptoms. It also inhibits histamine release from mast cells, providing an additional antiallergic mechanism.
Epinastine Hydrochloride is associated with:
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 168°C – 172°C |