Enoxacin is a synthetic fluoroquinolone antibacterial agent that inhibits bacterial DNA replication by targeting bacterial DNA gyrase and topoisomerase IV. It was developed as an oral antibacterial medicine for the treatment of susceptible bacterial infections.
Enoxacin belongs to the quinolone/fluoroquinolone class of antibacterial compounds. Its antibacterial activity results primarily from inhibition of bacterial enzymes required for DNA replication and transcription.
Enoxacin is a synthetic quinolone derivative with the molecular formula C₁₅H₁₇FN₄O₃ and molecular weight of approximately 320.33 g/mol. Its CAS number is 74011-58-8.
The compound has been investigated and used for susceptible bacterial infections, although its clinical availability and approved uses vary by country.
Swapnroop Drugs and Pharmaceuticals provides Enoxacin API for qualified pharmaceutical manufacturing, formulation development, research and pharmaceutical sourcing requirements.
Enoxacin is a specialized antibacterial API belonging to the fluoroquinolone class.
Enoxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV. These enzymes are essential for bacterial DNA replication, repair and transcription. Inhibition of these enzymes interferes with bacterial DNA processes and ultimately leads to bacterial cell death.
Enoxacin is associated with:
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Specific Rotation | -40.0° to -43.0° (c=1, MeOH) |
| Melting Point | 168°C – 172°C |