Enflurane is a halogenated inhalational general anaesthetic used to induce and maintain general anesthesia during surgical procedures. It is a volatile fluorinated ether and belongs to the class of inhalational anesthetic agents.
Enflurane produces reversible depression of the central nervous system, resulting in loss of consciousness and other effects required for general anesthesia. It is administered by inhalation using specialized anesthesia equipment.
Enflurane is a clear, colorless, volatile liquid with a characteristic ether-like odor. It is chemically known as 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether and has the molecular formula C₃H₂ClF₅O.
Enflurane has a molecular weight of approximately 184.49 g/mol and is classified as a halogenated inhalational anesthetic.
Enflurane is a specialized pharmaceutical anesthetic ingredient used in the manufacture and formulation of inhalational anesthetic products. It requires appropriate controls for identity, purity, volatile impurities, water content and other applicable quality attributes.
The precise mechanism of action of inhalational anesthetics such as Enflurane is complex and involves effects on multiple neuronal ion channels and central nervous system pathways. These actions produce reversible CNS depression and the clinical state of general anesthesia.
Enflurane is associated with:
Swapnroop Drugs and Pharmaceuticals provides Enflurane for qualified pharmaceutical sourcing, manufacturing and research requirements, subject to applicable regulatory requirements and product specifications.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 5.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 150°C – 154°C |