Enalapril Maleate API is a pharmaceutical-grade active pharmaceutical ingredient belonging to the angiotensin-converting enzyme (ACE) inhibitor class. It is the maleate salt of enalapril and is widely used in the development and manufacture of pharmaceutical formulations for the management of hypertension and heart failure.
Enalapril Maleate is a prodrug that is converted in the body to enalaprilat, its pharmacologically active metabolite. Enalaprilat inhibits angiotensin-converting enzyme, thereby reducing the formation of angiotensin II and helping lower blood pressure and reduce the workload on the heart.
Enalapril Maleate is typically supplied as a white or almost white crystalline powder. It has the molecular formula C₂₄H₃₂N₂O₉ and a molecular weight of approximately 492.52 g/mol. The compound is sparingly soluble in water and soluble in organic solvents such as methanol.
Swapnroop Drugs and Pharmaceuticals provides Enalapril Maleate API for pharmaceutical manufacturing, formulation development and other qualified pharmaceutical applications. Our Enalapril Maleate product is intended for customers seeking a reliable pharmaceutical-grade API with appropriate quality documentation and specifications.
Enalapril Maleate is commonly used in pharmaceutical formulations associated with:
After administration, Enalapril Maleate is converted to enalaprilat, which inhibits angiotensin-converting enzyme (ACE). ACE inhibition decreases the conversion of angiotensin I to angiotensin II. The resulting reduction in angiotensin II activity contributes to vasodilation and decreased aldosterone secretion, helping reduce blood pressure.
Enalapril Maleate API is evaluated using appropriate analytical procedures for identity, assay, related substances, loss on drying, residue on ignition, optical rotation, pH and other applicable quality parameters. Testing and release should be performed according to the applicable pharmacopoeial requirements and the manufacturer's approved specification.
For Enalapril Maleate API sourcing, bulk requirements, technical information and pharmaceutical manufacturing requirements, contact Swapnroop Drugs and Pharmaceuticals. Our team can provide product availability, specifications, documentation and commercial information based on your requirements.
Enalapril Maleate API is an established pharmaceutical ingredient for ACE inhibitor formulations, making it an important API for manufacturers and pharmaceutical formulation developers seeking quality-controlled Enalapril Maleate for their production requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 6.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |
| Specific Rotation | -40.0° to -43.0° (c=1, MeOH) |