Eletriptan Hydrobromide Beta, also known as Eletriptan HBr Beta Form or Eletriptan Hydrobromide β-Polymorph, is the beta crystalline polymorphic form of eletriptan hydrobromide. Eletriptan hydrobromide is a triptan-class pharmaceutical compound and selective 5-HT1B/5-HT1D receptor agonist associated with the acute treatment of migraine.
Eletriptan hydrobromide has the molecular formula C22H26N2O2S·HBr and molecular weight of approximately 463.43 g/mol. The CAS Registry Number is 177834-92-3.
The α-form and β-form represent different crystalline arrangements of the same chemical substance. Because polymorphic form can influence physical and pharmaceutical properties, identification and control of the beta form are important for solid-state pharmaceutical development.
Published research has characterized eletriptan hydrobromide polymorphs using analytical techniques including powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and infrared spectroscopy.
Eletriptan Hydrobromide Beta API is a specialized crystalline form of eletriptan hydrobromide intended for pharmaceutical development and related analytical applications. The beta polymorphic form should be confirmed using appropriate validated solid-state characterization methods.
For quality control, PXRD and DSC can be used alongside conventional API testing such as identification, assay, related substances, residual solvents and water content.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 168°C – 172°C |