Eletriptan Hydrobromide is the hydrobromide salt form of eletriptan, a selective serotonin 5-HT1B/5-HT1D receptor agonist belonging to the triptan class of antimigraine compounds. It is an orally active pharmaceutical ingredient associated with the acute treatment of migraine attacks, with or without aura.
Eletriptan Hydrobromide has the molecular formula C22H27BrN2O2S and a molecular weight of approximately 463.44 g/mol. Its CAS Registry Number is 177834-92-3.
Eletriptan acts primarily at serotonin 5-HT1B and 5-HT1D receptors. Activation of these receptors contributes to modulation of cranial blood vessels and trigeminal signaling involved in migraine.
Eletriptan Hydrobromide API is a pharmaceutical active ingredient used in the development and manufacture of migraine-treatment formulations. It is the salt form of eletriptan commonly used in pharmaceutical products.
For pharmaceutical development, Eletriptan Hydrobromide can be evaluated using conventional API analytical methods including identification, assay, related substances, residual solvents, water content and elemental impurity testing. Solid-state characterization may also be important because different crystalline polymorphic forms of eletriptan hydrobromide have been described.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |
| Melting Point | 150°C – 154°C |