Eletriptan Hydrobromide Alpha, also known as Eletriptan HBr Alpha Form or Eletriptan Hydrobromide α-Polymorph, is the alpha crystalline polymorphic form of eletriptan hydrobromide. Eletriptan hydrobromide is a triptan-class pharmaceutical compound and a selective 5-HT1B/5-HT1D receptor agonist used in the acute treatment of migraine.
Eletriptan hydrobromide has the molecular formula C22H26N2O2S·HBr and a molecular weight of 463.43 g/mol. Its CAS Registry Number is 177834-92-3.
The α-form and β-form of eletriptan hydrobromide are distinct crystalline polymorphs. Published research has characterized these forms using techniques including differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and diffuse reflectance infrared spectroscopy (DRIFTS). The α-form is reported as the more stable polymorph compared with the β-form.
Eletriptan Hydrobromide Alpha API is a specialized pharmaceutical-grade polymorphic form of eletriptan hydrobromide. Control of the crystalline form is important because polymorphism can affect physical and pharmaceutical properties.
For pharmaceutical applications, the α-polymorph should be characterized and controlled using appropriate solid-state analytical techniques, particularly PXRD and DSC, together with chemical purity and assay testing.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |
| Melting Point | 168°C – 172°C |