EGF, or Epidermal Growth Factor, is a recombinant human peptide used as a specialized cosmetic skin-conditioning ingredient. In cosmetic ingredient nomenclature, recombinant EGF is commonly identified as sh-Oligopeptide-1 or Oligopeptide-1.
EGF is a 53-amino-acid peptide produced using recombinant biotechnology and is widely used in advanced cosmetic formulations such as facial serums, creams, lotions, masks and other premium peptide-based skin-care products.
Epidermal Growth Factor (EGF) is a naturally occurring human signaling protein. Cosmetic EGF is commonly produced through recombinant biotechnology, including fermentation-based production using E. coli.
Recombinant EGF used in cosmetics contains 53 amino acids and has a molecular weight of approximately 6.2 kDa. The peptide contains three intramolecular disulfide bonds.
In cosmetic formulations, EGF is primarily used as a skin-conditioning ingredient.
EGF can be incorporated into cosmetic formulations where specialized peptide-based skin-conditioning ingredients are required.
Common formulation formats include:
EGF is generally used at very low active concentrations because it is a high-value recombinant peptide. The appropriate concentration should always be determined according to the supplier's technical documentation and the intended cosmetic application.
EGF is used in advanced skin-care formulations as a skin-conditioning peptide. It is particularly common in premium cosmetic products designed around peptide and growth-factor-inspired ingredient systems.
Potential applications include:
Formulators should consider:
Recombinant EGF is water-soluble and can be incorporated into suitable aqueous cosmetic systems. Commercial EGF materials may be supplied as powder or stabilized liquid preparations.
The actual solubility and recommended incorporation method depend on the commercial grade.
EGF is a protein-based cosmetic ingredient and should not be subjected unnecessarily to high temperatures.
Where appropriate, EGF can be incorporated during the cooler stage of formulation processing. The supplier's recommended processing conditions should always be followed.
Commercial EGF preparations can have a formulation-compatible pH range. One commercial recombinant EGF specification gives approximately pH 4–7.
The final formulation pH should be selected according to the specific EGF grade and overall formulation requirements.
EGF is sensitive to formulation and storage conditions. Commercial grades may require refrigerated storage, commonly around 2–8°C, while some stabilized preparations have different requirements.
The supplier's TDS, SDS and COA should be followed for exact storage conditions and shelf life.
EGF can be considered for:
EGF stands for Epidermal Growth Factor. In cosmetic formulations, recombinant human EGF is commonly identified as sh-Oligopeptide-1.
The commonly used cosmetic INCI name for recombinant EGF is sh-Oligopeptide-1.
The commonly assigned CAS number is 62253-63-8.
Recombinant human EGF has a molecular weight of approximately 6,222 g/mol, or approximately 6.2 kDa.
Recombinant human EGF contains 53 amino acids.
Yes. EGF is a recombinant protein/peptide consisting of 53 amino acids.
EGF is primarily used as a skin-conditioning cosmetic ingredient in advanced skin-care formulations.
Yes. Recombinant EGF can be supplied in water-soluble forms and is suitable for selected aqueous cosmetic systems.
Yes. EGF is commonly incorporated into specialized facial serum formulations.
Yes. EGF can be incorporated into suitable cosmetic creams and moisturizing formulations.
EGF is the common name for Epidermal Growth Factor, while sh-Oligopeptide-1 is the cosmetic INCI identity commonly used for recombinant human EGF.
Storage requirements depend on the commercial grade. Refrigerated storage around 2–8°C is common for some commercial preparations, but the supplier's TDS, SDS and COA should be followed.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white powder |