Edotreotide is a chelated octreotide derivative and peptide compound also known as DOTATOC. It contains the DOTA chelator and a modified octreotide peptide sequence designed to interact with somatostatin receptors, particularly somatostatin receptor subtype 2 (SSTR2).
Edotreotide is used as a peptide component in radiopharmaceutical applications when complexed with suitable radionuclides. For example, gallium-68 edotreotide (Ga-68 DOTATOC) is used for PET imaging of somatostatin-receptor-positive neuroendocrine tumors.
Edotreotide is a specialized peptide pharmaceutical ingredient requiring appropriate peptide synthesis, purification, characterization and quality-control procedures. It can be supplied for pharmaceutical research, development and radiopharmaceutical applications according to applicable specifications.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 150°C – 154°C |