Cyclopenthiazide is a thiazide-type diuretic and antihypertensive pharmaceutical active ingredient. It promotes the excretion of sodium and water through the kidneys and has been used in the management of hypertension and fluid retention associated with edema.
Cyclopenthiazide is a synthetic benzothiadiazine-related diuretic. It acts primarily on the renal tubules to reduce sodium and chloride reabsorption, increasing the urinary excretion of sodium and water.
Cyclopenthiazide is identified by CAS No. 742-36-7 and has the molecular formula C15H18ClN3O4S2 with a molecular weight of approximately 403.90 g/mol.
Cyclopenthiazide inhibits the sodium-chloride cotransporter (NCC) in the distal convoluted tubule of the nephron. This decreases sodium and chloride reabsorption and increases the excretion of sodium, chloride and water.
With continued administration, thiazide-type diuretics also contribute to a reduction in peripheral vascular resistance, supporting their antihypertensive effect.
Cyclopenthiazide has been used as a diuretic and antihypertensive agent for the management of hypertension and edema associated with certain medical conditions.
Its current availability, indications and regulatory status may vary between countries.
Cyclopenthiazide can be supplied for applicable pharmaceutical research, formulation development and manufacturing requirements, subject to relevant quality and regulatory standards.
Cyclopenthiazide API quality evaluation may include:
Final acceptance criteria should always be based on the approved product specification, validated analytical methods and batch-specific Certificate of Analysis (CoA).
Cyclopenthiazide intended for pharmaceutical manufacturing should be handled according to applicable GMP, quality-control and regulatory requirements. The appropriate specification should be established according to the intended market and applicable pharmacopoeial or customer requirements.
Cyclopenthiazide API should be stored in a tightly closed, suitable container under the manufacturer's recommended conditions. Exposure to excessive moisture, heat and unsuitable environmental conditions should be avoided.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0% by HPLC |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 1.0% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | NMT 0.5% |
| Water Content | NMT 1.0% |