Cyclacillin is a semi-synthetic penicillin-class β-lactam antibiotic developed for its antibacterial activity against susceptible microorganisms. It belongs to the aminopenicillin-related group of antibacterial agents and acts by interfering with bacterial cell-wall synthesis.
Cyclacillin is a β-lactam antibacterial compound that exerts its activity by binding to penicillin-binding proteins (PBPs) involved in the final stages of bacterial cell-wall formation. This disrupts peptidoglycan cross-linking and can lead to bacterial cell lysis.
Cyclacillin is identified by CAS No. 3485-14-1 and has molecular formula C19H27N3O5S.
Cyclacillin inhibits bacterial cell-wall synthesis by binding to susceptible penicillin-binding proteins. This prevents proper peptidoglycan cross-linking and weakens the bacterial cell wall, resulting in antibacterial activity.
Cyclacillin has been investigated and used as an antibacterial agent for infections caused by susceptible bacteria. Its current pharmaceutical availability and approved indications may vary according to jurisdiction and regulatory status.
Cyclacillin can be supplied for applicable pharmaceutical development, research, formulation and manufacturing requirements, subject to relevant quality and regulatory standards.
Quality evaluation may include identity, assay, related substances, water content, residue on ignition, pH, optical rotation, melting behavior, residual solvents and elemental impurities, as applicable.
Final acceptance criteria should always be based on the approved product specification, validated analytical methods and batch-specific Certificate of Analysis (CoA).
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Conforms to Cyclacillin identity by validated analytical methods such as HPLC, LC-MS and IR |
| Assay (HPLC) | NLT 95.0% by HPLC |
| Loss on Drying | NMT 5.0% |
| Residue on Ignition | NMT 1.0% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 3.5 – 6.5 |
| Individual Impurity | NMT 0.5% |
| Water Content | NMT 0.5% |
| Melting Point | 150°C – 154°C |