Crospovidone is a cross-linked, water-insoluble derivative of polyvinylpyrrolidone (Povidone) and is widely used as a high-performance pharmaceutical excipient. It is primarily used as a superdisintegrant in tablets and capsules to promote rapid tablet breakup and facilitate efficient drug release.
The cross-linked structure of Crospovidone provides excellent capillary activity and rapid liquid uptake. When exposed to aqueous media, it absorbs liquid and swells without forming a viscous gel, helping tablets disintegrate efficiently.
Swapnroop Pharma manufactures and supplies Crospovidone for pharmaceutical formulation applications, with product quality controlled according to applicable specifications and customer requirements.
Crospovidone is a cross-linked homopolymer of N-vinyl-2-pyrrolidone. Unlike soluble povidone, its cross-linked polymer structure makes it practically insoluble in water while retaining strong water-absorption and wicking properties.
It is commonly used in:
Crospovidone combines a porous particle structure with strong capillary action. These properties allow formulation liquids to penetrate rapidly through the tablet matrix.
Key functional properties include:
Crospovidone is mainly used as a superdisintegrant in solid oral dosage formulations.
Its rapid wicking action helps liquid penetrate the tablet, while the resulting swelling and mechanical action facilitate tablet breakup. This can contribute to improved drug dissolution and release characteristics.
Crospovidone may therefore be used in formulations requiring:
The appropriate concentration should be established according to the formulation design, API properties and manufacturing process.
Crospovidone is tested according to its applicable pharmaceutical grade and customer-approved specification. Quality evaluation may include:
For commercial pharmaceutical supply, the grade-specific CoA and approved product specification should be considered the controlling documents.
Swapnroop Pharma supplies Crospovidone as a pharmaceutical excipient for manufacturers of tablets, capsules and other solid oral dosage formulations.
Our Crospovidone offering is intended for applications where rapid disintegration, efficient water uptake and formulation consistency are important. Product specifications, packaging and documentation can be aligned with applicable customer requirements.
Crospovidone should be stored in tightly closed packaging under suitable cool, dry and well-ventilated conditions, protected from excessive moisture, contamination and adverse environmental exposure.
The recommended storage conditions should follow the applicable product specification and manufacturer's documentation.
Depending on the supply requirement, relevant documentation may include:
Swapnroop Pharma focuses on supplying quality pharmaceutical excipients for formulation and manufacturing applications.
Key advantages include:
Crospovidone is an important superdisintegrant for modern solid oral dosage formulations where rapid and reliable tablet disintegration is required.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |