Croscarmellose Sodium is a chemically modified, cross-linked cellulose derivative widely used as a pharmaceutical excipient in oral solid dosage forms. It is primarily used as a superdisintegrant to promote rapid breakup of tablets and facilitate the release of the active pharmaceutical ingredient.
Croscarmellose Sodium combines swelling and wicking mechanisms, allowing it to absorb water and expand rapidly within a tablet matrix. This makes it particularly valuable in conventional tablets, immediate-release formulations, and orally disintegrating dosage forms.
Croscarmellose Sodium is the sodium salt of internally cross-linked carboxymethylcellulose. The cross-linking reduces its solubility while maintaining its ability to absorb water and swell.
It is generally supplied as a white to off-white, free-flowing powder and is used at relatively low concentrations in tablet formulations.
Croscarmellose Sodium is commonly used in:
Croscarmellose Sodium provides:
Pharmaceutical-grade Croscarmellose Sodium should be evaluated according to the applicable pharmacopoeial and product-specific requirements. Typical testing may include:
Exact acceptance limits should be confirmed against the applicable USP/NF, Ph. Eur., BP, IP, or manufacturer-specific specification.
Swapnroop Pharma provides Croscarmellose Sodium for pharmaceutical formulation applications with emphasis on consistent quality, grade-specific specifications, batch control, and documentation support.
Croscarmellose Sodium can be supplied for applications requiring rapid tablet disintegration, improved water uptake, and efficient drug-release characteristics.
Croscarmellose Sodium should be stored in tightly closed packaging in a cool, dry and well-ventilated environment. Protect from moisture, excessive heat, direct sunlight, and contamination.
Because its performance depends on water uptake and swelling, exposure to excessive moisture should be avoided during storage.
Documentation may include:
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |