Cosyntropin is a synthetic analogue of adrenocorticotropic hormone (ACTH). It corresponds to the biologically active first 24 amino acids of human ACTH and stimulates the adrenal cortex to release corticosteroid hormones, particularly cortisol.
Cosyntropin is a synthetic peptide hormone used as a pharmaceutical active ingredient. It is also known as tetracosactide and ACTH 1-24. Cosyntropin has the amino-acid sequence corresponding to residues 1 through 24 of human corticotropin.
Cosyntropin is identified by CAS No. 16960-50-4 and has a molecular formula of C₁₃₆H₂₁₀N₄₀O₃₁S with a molecular weight of approximately 2933.49 g/mol.
Cosyntropin acts on melanocortin 2 receptors (MC2R) located on adrenal cortical cells. Receptor activation stimulates adrenal steroidogenesis and increases production and secretion of cortisol and other adrenal corticosteroids.
Cosyntropin is primarily used as a diagnostic agent for evaluation of adrenal cortical function. It is used in ACTH stimulation testing to assess the ability of the adrenal glands to produce cortisol.
Cosyntropin API can be supplied for pharmaceutical research, development, formulation and manufacturing applications, subject to applicable quality and regulatory requirements.
As a synthetic peptide, Cosyntropin quality evaluation may include identity, peptide content, purity, related peptides, water content, residual solvents, counter-ion content and biological activity/potency, as applicable.
Final acceptance criteria should always be based on the approved product specification, validated analytical methods and batch-specific Certificate of Analysis (CoA).
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 95.0% by HPLC |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Water Content | NMT 0.5% |
| Melting Point | 150°C – 154°C |