Corbadrine is a sympathomimetic pharmaceutical compound with predominantly alpha-adrenergic activity. It is also known as metaraminol, a vasopressor agent used to increase vascular tone and blood pressure in appropriate clinical settings.
Corbadrine is an active pharmaceutical ingredient associated with the phenethylamine/sympathomimetic class of compounds. It acts primarily through adrenergic mechanisms and produces vasoconstriction, resulting in an increase in vascular resistance and blood pressure.
Corbadrine is identified by CAS No. 54-49-9. Its molecular formula is C₉H₁₃NO₂ and its molecular weight is approximately 167.21 g/mol.
Corbadrine (metaraminol) has been used as a vasopressor for the management of hypotension associated with conditions such as anesthesia and other clinical situations where increased vascular tone may be required.
Corbadrine produces sympathomimetic effects primarily through alpha-adrenergic receptor stimulation and also has indirect adrenergic activity through promotion of norepinephrine release. Its pharmacological action results in vasoconstriction and increased blood pressure.
Corbadrine API can be supplied for pharmaceutical development, formulation and manufacturing applications, subject to applicable regulatory and quality requirements. Product documentation, analytical specifications and batch-specific quality information should be provided according to the applicable product specification.
Quality evaluation of Corbadrine API may include identification, assay, related substances, water content, residue on ignition, residual solvents and other applicable pharmaceutical quality parameters.
Final acceptance criteria should be established according to the approved product specification, validated analytical methods and applicable pharmacopoeial/regulatory requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Conforms to Corbadrine identity by validated analytical methods such as HPLC/LC-MS/IR, as applicable |
| Assay (HPLC) | NLT 98.0% by HPLC |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.0–7.0 |
| Individual Impurity | NMT 1.0% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |
| Melting Point | 151–154°C |