Colfosceril Palmitate, also known as Dipalmitoylphosphatidylcholine (DPPC) or 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, is a synthetic phospholipid and pulmonary surfactant component. It is an important phosphatidylcholine found in pulmonary surfactant and is associated with reducing surface tension at the alveolar air-liquid interface.
Colfosceril Palmitate is supplied as a pharmaceutical and specialty phospholipid ingredient for applications involving pulmonary surfactant formulations and lipid-based pharmaceutical research. Its chemical identity and quality can be characterized through spectroscopic identification, purity/assay testing, optical rotation and other product-specific analytical parameters.
Colfosceril Palmitate is chemically identified as a phosphatidylcholine containing two palmitoyl groups. Its molecular formula is C₄₀H₈₀NO₈P and its molecular weight is approximately 734.04 g/mol.
Colfosceril Palmitate has been used as a synthetic pulmonary surfactant and is associated with the management of respiratory distress syndrome in premature infants. It has also been used as a component in surfactant and lipid-based pharmaceutical research.
Quality evaluation of Colfosceril Palmitate may include:
A commercial analytical specification for DPPC, for example, lists white powder appearance, conforming infrared identification, titrimetric purity of at least 97.5%, and specific optical rotation of +6° to +8° under stated conditions. Use your actual approved CoA/specification for the commercial product rather than treating these values as a universal pharmaceutical specification.
Store Colfosceril Palmitate in a tightly closed container under controlled conditions, protected from excessive heat, moisture, light and contamination. Follow the applicable product specification and SDS for exact storage and handling requirements.
Colfosceril Palmitate can be supplied to qualified pharmaceutical manufacturers, formulation developers, research organizations and other customers requiring pharmaceutical or specialty phospholipid materials. Product documentation such as CoA, SDS and technical specifications can be provided according to applicable requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| pH (1% Solution) | 2.0 – 4.0 |
| Water Content | NMT 0.5% |
| Melting Point | 168°C – 172°C |