Cofrogliptin is a pharmaceutical active pharmaceutical ingredient (API) belonging to the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It is an orally active small-molecule compound investigated for its glucose-lowering activity and potential use in the management of type 2 diabetes mellitus.
Cofrogliptin is chemically identified as a DPP-4 inhibitor and has been investigated as a once-weekly treatment option because of its prolonged pharmacological activity.
Cofrogliptin API is supplied for pharmaceutical research, formulation development and manufacturing applications. The API is subject to appropriate analytical quality controls covering identity, purity, assay and other relevant quality attributes.
Cofrogliptin is a selective DPP-4 inhibitor investigated for its ability to increase incretin activity and improve glucose regulation. DPP-4 inhibition helps reduce degradation of incretin hormones such as GLP-1 and GIP, supporting glucose-dependent insulin secretion.
Cofrogliptin API should be tested using validated analytical methods appropriate for the material. Quality evaluation may include identification, assay, related substances, water content, residue on ignition, residual solvents and other applicable pharmaceutical quality parameters.
Relevant documentation may include Certificate of Analysis (CoA), specification sheet, Safety Data Sheet (SDS) and technical documentation, depending on the supply requirement.
Store Cofrogliptin in a tightly closed container under the storage conditions specified in the applicable product specification and SDS. Protect the material from excessive heat, moisture and direct light. Handle according to appropriate pharmaceutical material-handling procedures.
Cofrogliptin API can be supplied to qualified pharmaceutical manufacturers, formulation companies, research organizations and distributors, subject to applicable regulatory and commercial requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Individual Impurity | ≤ 0.5% |
| Melting Point | 150°C – 154°C |