Clonidine Hydrochloride is a pharmaceutical active ingredient belonging to the centrally acting alpha-2 adrenergic agonist class. It is the hydrochloride salt of clonidine and is used in pharmaceutical formulations for its effects on the central nervous system and sympathetic nervous activity.
Clonidine Hydrochloride is identified by CAS Number 4205-90-7 and has the molecular formula C9H10Cl2N4 with a molecular weight of 230.09 g/mol.
Clonidine acts primarily through stimulation of central alpha-2 adrenergic receptors, reducing sympathetic outflow from the central nervous system. This pharmacological action is associated with its use in formulations for hypertension and certain other therapeutic applications.
Clonidine Hydrochloride is used in pharmaceutical formulations primarily for:
Clonidine Hydrochloride API is evaluated through pharmaceutical quality-control testing including identity, assay, related substances, water or drying characteristics and other applicable quality attributes.
Store in a well-closed container, protected from light and moisture, under the storage conditions specified by the manufacturer.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Conforms to USP identification tests |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Water Content | About 305°C (decomposition) |